In addition to microscopy and molecular methods, there are methods for detecting malaria parasites on the basis of antigens or enzymatic activities associated with the parasites.

These methods include, among others:

• detection of an antigen (histidine rich protein-2, HRP-2) associated with malaria parasites (especially P. falciparum and P. vivax)
• detection of a Plasmodium associated lactate dehydrogenase (pLDH) either through its enzymatic activity or by immunoassay

The detection of HRP-2 and of pLDH forms the basis for diagnostic kits that have been, and continue to be evaluated.  Consensus information, when available, will be reviewed.