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| [Toxoplasma
gondii] |
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Members of the
cat family (Felidae) are the only known definitive hosts for the sexual
stages of T. gondii and thus are the main reservoirs of infection.
Cats become infected with T. gondii by carnivorism
.
After tissue cysts or oocysts are ingested by the cat, viable organisms
are released and invade epithelial cells of the small intestine where they
undergo an asexual followed by a sexual cycle and then form oocysts, which
are then excreted. The unsporulated oocyst takes 1 to 5 days after
excretion to sporulate (become infective). Although cats shed
oocysts for only 1 to 2 weeks, large numbers may be shed. Oocysts
can survive in the environment for several months and are remarkably
resistant to disinfectants, freezing, and drying, but are killed by
heating to 70°C for 10 minutes.
Human infection may be acquired in several ways: A) ingestion of
undercooked infected meat containing Toxoplasma cysts
;
B) ingestion of the oocyst from fecally contaminated hands or food
;
C) organ transplantation or blood transfusion; D) transplacental
transmission; E) accidental inoculation of tachyzoites. The
parasites form tissue cysts, most commonly in skeletal muscle, myocardium,
and brain; these cysts may remain throughout the life of the host.
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